Posaconazole is a triazole antifungal drug.mode of action:-posaconazole works by disrupting the close packing of acyl chains of phospholipids, impairing the functions of certain membrane-bound enzyme systems such as atpase and enzymes of the electron transport system, thus inhibiting growth of the fungi. it does this by blocking the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14a-demethylase and accumulation of methylated sterol precursors. posaconazole is significantly more potent at inhibiting 14-alpha demethylase than itraconazole.posaconazole is active against the following microorganisms:-candida spp.-aspergillus spp.-zygomycetes spp.