About sulphasalazinecomposed of 5-aminosalicylic acid and sulfapyridine, anti-infective (in inflammatory bowel disease),anti arthritic.mechanism of action of sulphasalazinesulfasalazine exerts its anti-inflammatory action by inhibiting lipoxygenase enzyme. this will leads to decreased production of pro-inflammatory leukotrienes (ltb4) and 5-hydroxy eicosa tetra enoic acids (hete) in the intestinal wall. it inhibits the production of inflammatory mediators like interleukin-1, tumor necrosis factor-alpha etcindications for sulphasalazine1. ulcerative colitis 2. crohn`s disease 3. rheumatoid arthritis 4. diarrhea interactions for sulphasalazinefolic acid : signs of folic deficiency with sulphasalazine. digoxin : possibly reduced efficacy of digoxin.