Therapeutic indication:the prevention of premature luteinising-hormone surges in women undergoing controlled ovarian hyperstimulation for assisted reproduction techniques.in clinical studies, orgalutran was used with recombinant human follicle-stimulating hormone or corifollitropin alfa, the sustained follicle stimulant.what is orgalutran used for?orgalutran is used to prevent premature ovulation (early release of eggs from the ovary) in women having fertility treatment and who are having ovarian stimulation (stimulation of the ovaries so that they produce more eggs). in premature ovulation, the ovaries release eggs that may be immature and not suitable for use in techniques such as in-vitro fertilisation.how does orgalutran work?the active substance in orgalutran, ganirelix, blocks the receptors for a natural hormone called gonadotrophin-releasing hormone (gnrh). gnrh controls the secretion of another hormone called luteinising hormone (lh), which causes ovulat