Napizole infusion (omeprazole 40 mg) for intravenous use is indicated as an alternative to oral therapy for the treatment of duodenal ulcers, gastric ulcers, in combination with appropriate antibiotics for the eradication of Helicobacter pylori in peptic ulcer disease the treatment of reflux oesophagitis.


About omeprazoleproton pump inhibitor, substituted benzimidazole, anti-secretory,antiulcer.mechanism of action of omeprazoleomeprazole is a proton pump inhibitor and it is a prodrug. after administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. in the acidic medium omeprazole is converted to sulfenamide. this sulfenamide covalently interacts with sulfhydryl (sh) group in the proton pump (h+ k+atpase) and inhibits the exchange of extracellular k+ for intracellular h+ ion. omeprazole irreversibly inhibits proton pumps activity and decreases gastric acid secretion.