About zaleplonpyrazolopyrimidine derivative( a nonbenzodiazepine, sedative-hypnotic.mechanism of action of zaleplonzaleplon is a non benzodiazepine sedative-hypnotic drug. it binds to the benzodiazepine binding site on gaba-a receptors containing the alpha 1 receptor sub unit and alters the gaba mediated chloride channel opening. this is responsible for sedative effect of the drug.interactions for zaleplonrifampin: it reduces the auc of zaleplon. cimetidine: it increases the cmax and auc of zaleplon. food: if zaleplon is taken with or immediately after fatty meal its effect on sleep onset may be reduced.