About sevelamerphosphate binder, management of hyperphosphataemia,urinary alkalinizer.mechanism of action of sevelamersevelamer is a phosphate binder. it is used to reduce the level of phosphorus in chronic renal disease. it binds with phosphate in the gastrointestinal tract and decreases phosphate absorption. these amines (sevelamer) exist in a protonated form in the intestine and interact with phosphate molecules. it binds with phosphate in the dietary tract and decreases absorption. sevelamer lowers the phosphate concentration in the serum. indications for sevelamerhyperphosphataemia in chronic kidney diseasetypical dosage for sevelameradult: 800 to 1600 mg / day in divided doses.