Entacapone (inn) is a medication commonly used in combination with other medications for the treatment of parkinson s disease. entacapone together with levodopa and carbidopa allows levodopa to have a longer effect in the brain and reduces parkinson
s disease signs and symptoms for a greater length of time than levodopa and carbidopa therapy alone.entacapone is known as a selective and reversible inhibitor of the enzyme catechol-o-methyltransferase (comt). when taken together with levodopa (l-dopa) and carbidopa, entacapone stops catechol-o-methyltransferase from breaking down and metabolizing levodopa, resulting in an overall increase of levodopa remaining in the brain and body.