About zopiclonea non-benzodiazepine, a cyclopyrrolone derivative, hypnotic,sedative.mechanism of action of zopiclonezopiclone is a non benzodiazepine sedative hypnotic drug. it has agonistic action on omega1 binding site of alpha1 gaba-a receptor subunit. zopiclone potentiates the action of gaba and decreases firing rate of neurons. this will produce a sedative-hypnotic effect.indications for zopiclone1. insomniainteractions for zopiclonemetoclopramide: concomitant administration may increase the plasma concentration of zopiclone. atropine: may decrease its plasma concentration, when given concurrently. trimipramine: if given along with zopiclone may result in lessened antidepressant effect of the former.