About zolmitriptanselective serotonin (5ht1) agonists, anti migrainemechanism of action of zolmitriptanzolmitriptan is a selective agonist for serotonin (5ht1 receptors). it relieves migraine by selective constriction of intracranial blood vessels, neuropeptide release inhibition and decreased transmission in the trigeminal pain pathwayindications for zolmitriptanacute migraine attackinteractions for zolmitriptanincreased risk of serotonin syndrome with ssri, selective serotonin- and norepinephrine-reuptake inhibitors (snri) increased zolmitriptan concentrations with cimetidine, quinolone antibacterials and drugs that inhibit the cytochrome p450 isoenzyme cyp1a2