About dorzolamidecarbonic anhydrase inhibitor, thiophene derivative, a sulfonamide, antiglucoma.mechanism of action of dorzolamidedorzolamide is a sulfonamide used as topical carbonic anhydrase inhibitor. inhibition of carbonic anhydrase-2 in ciliary processes of eye leads to reducing intra ocular tension by decreasing aqueous humor secretion by slowing the formation of bicarbonate ions with subsequent decrease in sodium and fluid transport.indications for dorzolamide1. ocular hypertension 2. open angle glaucoma interactions for dorzolamidesimilar to diuretics (carbonic anhydrase inhibitor) ? as possibility of systemic absorption after topical administration.