Composition

Each 1 ml or 1 g contains:
Tobramycin ................................................................................. 3 mg

Indications

Treatment of external ocular infections caused by susceptible bacteria.

Dosage and Administration

TOBRIN Sterile Ophthalmic Solution:
Mild to moderate disease: Instill 1 or 2 drops into the affected eye(s) every 4 - 6 hours.
Severe infections: Instill 2 drops into the eye(s) every hour until improvement. Reduce treatment prior to discontinuation.
TOBRIN Sterile Eye Ointment:
Mild to moderate disease: Apply about 1.5 cm ribbon into the affected eye(s) 2 or 3 times daily.
Severe infections: Apply about 1.5 cm ribbon into the affected eye(s) every 3-4 hours until improvement. Reduce treatment prior to discontinuation.
TOBRIN Sterile Eye Ointment may be used in conjunction with TOBRIN Sterile Ophthalmic Solution.
TOBRIN ophthalmic preparations should be used only during one month after opening.

Contraindications

Hypersensitivity to the drug or to other aminoglycoside antibiotics.

Warnings and Precautions

TOBRIN Sterile Ophthalmic Solution is Not for injection into the eye.
Prolonged therapy with TOBRIN as with antibiotics, may result in superinfection with nonsuceptible organisms, including fungi.
Cross-sensitivity to other aminoglycoside antibiotics may occur.
Patients should discontinue the drug at the first sign of a skin rash or other allergic reactions.
TOBRIN ophthalmic preparations should be used with caution in pregnancy or lactation. The drug may be used only if the potential benefit justifies the potential risk.
Contact lenses should be removed prior to administration of TOBRIN.
Lenses may be reinserted 15 minutes following adminstration of TOBRIN.
If more than one topical ophthalmic drug is being used, the drugs should be administered at least 10 minutes apart.
Patients should avoid allowing the tip of the dispensing container to contact the eye(s) or surrounding structures to avoid bacterial contamination