Metacardia MR (trimetazidine dihydrochoride) is indicated in adults as add-on therapy for the symptomatic treatment of patients with stable angina pectoris who are inadequately controlled by or intolerant to first-line anti-anginal therapy.


About trimetazidinecytoprotective,vasodilator, anti-ischemic (anti-anginal) agent.mechanism of action of trimetazidineit is a cytoprotective drug which reduces anginal attacks and improves exercise tolerance by nonhaemodynamic mechanisms. it improves cellular tolerance to ischaemia by: - 1) inhibiting mitochondrial long chain 3-ketoacyl-coa-thiolase- a key enzyme in fatty acid oxidation and there by reducing fatty acid metabolism and increasing glucose metabolism in myocardium. 2) limiting intracellular acidosis and sodium and calcium accumulation during ischaemia. 3) protecting against o* free radical induced membrane damage