About pimecrolimusimmunomodulator, macrolactam and is a derivative of ascomycinmechanism of action of pimecrolimuspimecrolimus binds with high affinity to macrophilin-12 (fkbp-12) and inhibits the calcium-dependent phosphatase, calcineurin. as a consequence, it inhibits t cell activation by blocking the transcription of early cytokines. in particular, pimecrolimus inhibits at nanomolar concentrations interleukin-2 and interferon gamma (th1-type) and interleukin-4 and interleukin-10 (th2-type) cytokine synthesis in human t cells. also, pimecrolimus prevents the release of inflammatory cytokines and mediators from mast cells in vitro after stimulation by antigen/lge