Composition

Each tablet contains:
Secnidazole ....................................................................
500 mg

Therapeutic Indications

Intestinal and hepatic amoebiasis.

Trichomal infections of the urogenital tract.


Dosage and Administration

Adults:
Acute intestinal amebiasis: 4 tablets taken as a single dose for one day.

Hepatic amebiasis: 3 tablets taken as a single dose for 5 days.

Urogenital trichomoniasis: 4 tablets taken as a single dose for one day.

Children:
Acute intestinal amebiasis: 30 mg/kg body weight as a single dose or several divided doses for one day.

Hepatic amebiasis: 30 mg/kg body weight as a single dose or several divided doses for 5 days.


Contraindications

Pregnancy especially in the first trimester.

Nursing mothers.

Epilepsy or organic CNS disease.


Warnings and Precautions

Secnidazole should be used with great care in patients with blood dyscrasias or with active disease of the central nervous system.

Overdose treatment:
If recently taken, it is recommended to carry out gastric lavage; then continuation of treatment, if necessary, should be symptomatic and supportive.


Drug Interactions

Precautions must be taken if secnidazole is taken concurrently with alcohol or drugs formulated with alcohol as it may provoke a disulfiram-like reaction in some individuals.

Concurrent use of secnidazole with disulfiram may cause acute psychoses or confusion.


Undesirable Effects

It may cause, in few cases, gastrointestinal disturbances especially nausea and vomiting.

It may cause headache, anorexia or rarely pseudomembranous colitis.