This is a unique triple-combination topical therapy for the short-term (8-week ) treatment of the dark spots associated with moderate-to-severe facial melasma.1.fluocinolone acetonide 0.01% is a mild corticosteroid that reduces inflammation.2.hydroquinone 4% is a depigmenting agent that interrupts the formation and synthesis of melanin to help lighten the skin.3.tretinoin 0.05% works by increasing the skin cell turnover rate, which helps exfoliate the skin.this cream should always be used in conjunction with sun-avoidance measures, like using sunscreens and wearing protective clothing. it may improve the appearance of melasma but is not a cure.