About capsaicina lipophilic capsaicinoid(methyl vanillyl nonenamide),substance p release inducer, a topical analgesic ,antineuralgic and antipruritic, rubefacient.about methyl salicylatesalicylates, rubefacient, counterirritant.mechanism of action of methyl salicylatemethyl salicylate is a rubefacient. it produces reddening of the skin by dilatation of the blood vessel and gives a soothing feeling of warmth. it is also called as counterirritant because they produce their action by counter irritation. irritation of the sensory nerve endings alters pain in the underlying muscle or joints that are served by the same nerves.about mentholterpenes and terpenoid, antipruritic, decongestant, topical analgesic.mechanism of action of mentholmenthol acts as a local anesthetic on the respiratory passageways and causing cough suppression. when menthol is rubbed on the skin, it acts as a rubefacient and causes localized vasodilatation- which gives feelings of comfort and warmth. wh