About tegaserodserotonin 5-ht4 agonist, a motility stimulant. mechanism of action of tegaserodtegaserod is a 5ht4 agonist with negligible affinity for other receptor subtypes. binding of tegaserod to the 5ht4 receptor will enhances gastrointestinal motility and accelerates transit time in the gastrointestinal tract. it also stimulates chloride secretions and reduces the sensitivity of the intestinal pain-sensing nerves and can thereby reduce the perception of pain.indications for tegaserod1. chronic constipation 2. irritable bowel syndrome with constipation in women interactions for tegaserodthere was no effect on the pharmacokinetics of digoxin, oral contraceptives, and warfarin. dextromethorphan: a pharmacokinetic interaction study demonstrated that co-administration of tegaserod and dextromethorphan did not change the pharmacokinetics of either compound to a clinically relevant extent. dose adjustment of either drug is not necessary when tegaserod is combined wit