Indication for the treatment of symptomatic orthostatic hypotension (oh).mechanism of actionmidodrine forms an active metabolite, desglymidodrine, that is an alpha1-agonist, and exerts its actions via activation of the alpha-adrenergic receptors of the arteriolar and venous vasculature, producing an increase in vascular tone and elevation of blood pressure. desglymidodrine does not stimulate cardiac beta-adrenergic receptors.