About methylphenidatepsychostimulant, sympathomimetic ,piperidine class.mechanism of action of methylphenidatemethylphenidate activates the brain stem arousal system and cortex. blocking the reuptake of dopamine into nerve terminals (as well as stimulating the release of dopamine from dopamine nerve terminals) resulting in increased dopamine levels in the synapse.indications for methylphenidate1.attention-deficit hyperactivity disorder ( adhd ) 2.narcolepsy interactions for methylphenidate1) adrenergic agonist drugs or pemoline with methylphenidate increases the risk of liver toxicity 2) drugs that elevate bp including maois, coumarin, anticoagulants, anticonvulsants, tricyclic antidepressants, dopa, antipsychotics, phenylbutazone. alcohol.