Evolocumab is a monoclonal antibody designed for the treatment of hyperlipidemia.evolocumab is a fully human monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9 (pcsk9). pcsk9 is a protein that targets ldl receptors for degradation and thereby reduces the liver s ability to remove ldl-c, or "bad" cholesterol, from the blood.