Abstract5 articaine preparations including besides 4% articaine with epinephrine 1:100 000 and 1:200 000, 4% articaine with epinephrine 1:400 000, 2% articaine 1:200 000 and articaine without a vasoconstrictor were investigated on 52 volunteers, dental students. it was established that new combinations of articaine with epinephrine had relatively high activity to anesthetize dental pulp which was comparable with classic agents but slightly inferior to them in all the criteria studied. articaine without adrenaline had not practically induced pulpal analgesia.