Magna-Biotic
(Vials)
Composition:
Composition Vials
600 mg 1200 mg
Amoxycillin (as Sodium salt) 500 mg 1000 mg
Clavulanic acid (as Potassium salt) 100 mg 200 mg
Properties:
Magnabiotic is an anti-microbial combination of Amoxicillin & Clavulinic acid.
Amoxycillin: Is a broad spectrum semi-synthetic penicillin against Gram +ve & Gram-ve micro-organisms.
Clavulanic acid: Is a B-lactam structurally related to Penicillins that inactivate B-lactamase enzymes commonly found in micro-organisms resistant to penicillin .
The combination of Amoxycillin / Clavulanic acid extends the antibiotic spectrum of Amoxycillin to include bacteria normally resistant to Amoxycillin & other B-lactam antibiotics.
Magnabiotic is well absorbed from G.I.T after oral administration, stable in the presence of gastric acid & may be administered with out regard to to meals.
About 50-70 % of Magnabiotic is excreted unchanged in urine during the first 6 hours after oral administration .
It diffuses readily into most body tissues & fluids & can be detected in middle ear effusion .

Magna-biotic VialIndications:
Upper respiratory tract & E.N.T infections :
Sinusitis, tonsillitis, pharyngitis , laryngitis, otitis media,etc...
Lower respiratory tract infections :
Bronchitis, pneumonia, emphysema, lung abscess etc....
Gastrointestinal infections :
Enteritis, billary tract infection.
Genito-urinary tract infections :
Cystitis, urethritis, gonorrhea etc...
Skin & soft tissue infections :
Cellulitis, erysipelas, boils, carbuncles ,etc...
others : Septicemia, osteomyelitis, etc...
Contraindications:
A history of allergic reactions to any Penicillin is a contraindication.

Method of reconstitution & administration:
N.B.:
Vial of Magnabiotic is not suitable for multi-dose use.
Magna-Biotic may be administrated either by intravenous injection or by intermittent I.V.
infusion.

(Magna-Biotic is not intended for intra-muscular administration)
-600 mg vials: to reconstitute dissolve contents in 10 ml of water for injection B.P.(final volume
10.5 ml)
-1200 mg vial: to reconstitute dissolve contents in 20 ml of water for injection B.P.(final volume 20.9 ml)
-A transient pink color may appear during reconstitution.
Reconstituted solutions are normally a pale straw color.

Intravenous injection:
The stability of Magna-Biotic intravenous solutions is concentration dependent,thus Magna-Biotic (I.V.
injection or slowly I.V.
infusion) should be used immediately upon reconstitution and given by slow I.V.
injection over a period of 3-4 minutes.

Intravenous Infusion:
Magna-Biotic intravenous may be infused in water for injection BP.
or (0.9 % w/v sodium chloride intravenous injection BP.)

Add 600 mg of the reconstituted solution to 50 ml of infusion fluid or 1200 mg reconstituted solution to 100 ml of infusion fluid (preferably using a mini-bag or line burette) infuse over 30-40 minutes and complete within 4 hours of reconstitution.
Any residual antibiotic solution should be discarded.

Warning:
Hepatically impaired patients should be dosed with caution and hepatic function monitored at regular intervals.

Dosage:
(I.V.
injection or infusion) Adults and children over 12 years:1200 mg every 8 hours.
In serious infections: 1200 mg every 6 hours.
Children:
-3 months - 12 years: 30 mg/kg every 8 hours.
-In more serious infections : 30 mg/kg every 6 hours.
-Children less than 3 months: 30 mg/kg every 12 hours (In premature infants and in full term infants during the prenatal period)increasing to 8 hourly intervals there after.
Side effects:
Magnabiotic is generally well tolerated.
The majority of side effects are mild & transient and consist mainly of diarrhea, nausea, abdominal discomfort, skin rashes & urticaria which disappear upon discontinuation of therapy.

Storage:
Keep in a cool dry place at temp.
less than 25ºC.
Keep medicine out of reach of children.

Presentation:
Intravenous vials for injection or infusion of 600 mg / vial or 1200 mg/ vial