Mphotericin-bit is a polyene antifungal antibiotic.indications for amphotericin-b


1.oral, cutaneous, vaginal candidiasis


2.otomycosis


3.mucocutaneous candidiasis


4.fungal meningitis


5.kala azar


6.cryptococcosis


7.histoplasmosis


8.coccidioidomycosis


9.blastomycosis


10.paracoccidioidomycosis 1


1.aspergillosis 1


2.sporotrichosis 1


3.systemic mycoses mechanism of action of amphotericin-bamphotericin b has high affinity for ergosterol present in the fungal cell membrane and bind with it and they orients in such a way that micropore channel are formed and leads to efflux of ions, amino acid, sugar and other water soluble substances and results in cell disruption.