Therapeutic indications:symptomatic venous insufficiency- states of capillary fragility in post - hemorrhoidectomy patients.posology and method of administration:1-3 ampoules a day by intramuscular injection. the content of the ampoules must not be mixed with solutions containing ascorbic acid.disease areasurgery, trauma and infections promote edema. they trigger neutrophil-endothelial interaction which induces the synthesis of many inflammatory mediators, e.g., il-1- pge-2- tnf-alpha. inflammation causes pain, vasodilatation, increased capillary permeability and fluid exudation to the interstitial spaces. inflammation also activates the coagulation cascade increasing the intravascular thrombosis. venous thrombosis causes capillary hypertension that aggravates edema.