About ifosfamidealkylating agent (nitrogen mustard), antineoplasticmechanism of action of ifosfamidein the liver drug undergo enzymatic activation into 4-hydroxyifosfamide.this alkylates the dna by binding to n7 position of the guanine residue. this results cross linking/abnormal base pairing/scission of dna strand. there is cross linking of nucleic acid with proteins can also takes place. the overall process is cell cycle nonspecific reaction.ssindications for ifosfamides1. testicular cancer s2. breast cancer s3. non-hodgkins disease s4. hodgkins disease s5. soft tissue sarcoma s6. osteogenic sarcoma s7. lung cancer s8. cervical cancer s9. ovarian cancer s10. lymphocytic lymphoma s11. gastric cancer s12. pancreatic cancer s13. bladder cancer s14. cancer of endometrium s15. neuroblastoma s16. wilm`s tumor s