About cefoperazone sodiuma third generation cephalosporin antibiotic, parenteral antibiotic.mechanism of action of cefoperazone sodiumcefoperazone is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. cefoperazone inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like cefoperazone. it has greater action against pseudomonas & has good action against salmonella typhi & b.fragilisindications for cefoperazone sodium1.meningitis 2.biliary infections 3.septicemia 4.infections in immunocompromised patients 5.urinary tract &genital tract infections 6.surgical prophylaxis 7.skin & soft tissue infections 8.bone & joint infections 9.gonorrhea, 10.peritonitis.