Properties:
Metoclopramide hydrochloride is a substituted benzamide which have a direct effect on chemoreceptor trigger zone and antagonize dopamine and serotonin receptors. It stimulates the motility of the upper gastro -intestinal tract without affecting gastric acid secretion. Metoclopramide also increases gastric peristalsis leading to accelerated gastric emptying, duodenal peristalsis is also increased and thus decreases intestinal transit time. The resting tone of gastro-esophageal sphincter is increased and pyloric sphincter is relaxed. The elimination half life of Metoclopramide is about 6 hours. Urinary excretion appears to be the main route of elimination of Metoclopramide.