About diltiazema benzothiazepine derivative, calcium channel blocker, anti hypertensive, anti-anginal, class iv antiarrhythmic.ssmechanism of action of diltiazemsdiltiazem is a benzothiazepine- ca channel blocker. it exerts it`s antianginal, antihypertensive, antiarrythmic actions through blocking the influx of ca ions through voltage gated l-type ca channels to the peripheral vascular smooth muscle cells, coronary smooth muscle cells and to the myocardial cells. thus causes dilatation of vascular endothelium, decrease peripheral resistance, and decrease bp in hypertensive individuals. sindications for diltiazem1. hypertension 2. prinzmetal`s angina 3. stable angina