About mitoxantronean anthracenedione derivative, a type ii topoisomerase inhibitor, anti-neoplastic.mechanism of action of mitoxantronethis drug shows its anticancer activity by different mechanisms. drug intercalates the dna cause inter/intra strand cross linking. the drug can also bind to the topoisomerase enzyme2, which is necessary for the cell to divide and so grow into 2 new cells. if the drug binds with dna it gets tangled up and the cell cannot divide. this is cell cycle phase-nonspecificindications for mitoxantrone1. chronic myelogenous leukemia 2. non hodgkins disease 3. breast cancer 4. acute non lymphocytic leukemia 5. hormone-refractory prostate cancer 6. multiple sclerosis 7. lymphomas 8. gastric cancer 9. liver cancer 10. ovarian cancer 11. prostate cancer