About bromazepambenzodiazepine derivative,anxiolytic,sedative,hypnotic,skeletal muscle relaxantmechanism of action of bromazepambromazepam binds to the gaba receptor gabaa. these will facilitates gaba mediated chloride channel opening and produce hyperpolarisation.this will produce an increase in the concentration of inhibitory neurotransmitter gaba and chloride ions and decreases firing rate of neurons.these alter normal excitatory functions of the body.indications for bromazepam1.anxiety 2.preanaesthetic medication 3.epigastric pain 4.hypertension 5.insomnia interactions for bromazepamalcohol and other cns depressants>>enhanced cns effect cemetidine,disulfiram,fluoxetine,isoniazid,ketoconazole,propranalol,propoxyphene, valproic acid: bromazepam activity enhanced digoxin,imipiramine&desipramine:enhanced activity of these drugs levodopa:decrease in antiparkinsonism efficacy