About metforminbiguanide derivative, oral anti-diabetic.mechanism of action of metforminit is a biguanide which exerts antidiabetic action. the drug suppresses gluconeogenesis in liver and thus suppresses hepatic glucose output. it enhance insulin mediated glucose disposal in muscle and adipose tissue. it enhance glut1 (glucose transporter-1) transport from intracellular site to plasma membrane. it also interferes with respiratory chain in mitochondria and promotes peripheral glucose utilization by increasing anaerobic glycolysis. it inhibits intestinal absorption of glucose, other hexose sugars, amino acids and vitamin b12. it also improves lipid profile in type-2 diabetics.indications for glibenclamide1. non insulin dependent diabetes mellitus. interactions for glibenclamidehypoglycaemic effect of glibenclamide is enhanced by: anticoagulants, androgens, chloramphenicol, clofibrate, fenfluramine, fluconazole, gemfibrozil, histamine h2 antagonists, magnesium salts, methyl