About estriolsone of the three main naturally occurring estrogens, estrogen replacement. sduration of action for estriols7 days.sside effects of estriolslocal genital irritation and burning. scontra-indications of estriolsprecarcinomatous lesions of vulva or vagina. breast, genital or oestrogen dependent carcinoma. thromboembolic disorders. cerebrovascular disease, undiagnosed vaginal bleeding.sspecial precautions while taking estriolsin infectious pruritis of vulvae give specific therapy. sspregnancy related informationscontraindicated.sindications for estriolssenile or atrophic vaginitis. preoperative preparation of the vagina. dyspareunia in menopausal states.sinteractions for estriolsinteractions seen only when used systemically. now-a-days only used locally as a cream. soral anticoagulants : anticoagulant effect antagonized. s