About irbesartansangiotensin ii receptor blocker, a non-peptide compound, antihypertensive.ssmechanism of action of irbesartansit is a competitive antagonist of angiotensin-2 at at-1 receptor. it decreases peripheral resistance and lowers bp in hypertensive individuals. it blocks all overt actions of angiotensin-2 such as: - 1. vasoconstriction, 2. central & peripheral sympathetic stimulus, 3. release of aldosterone and adrenaline, 4. salt and water reabsorption, 5. central actions like thirst, vasopressin release, and growth promoting actions on heart and blood vessels.ssindications for irbesartans1. hypertensionssinteractions for irbesartansno significant interactions have been found in concomitant use with hydrochlorothiazide, digoxin, warfarin and nifedipine.