Indication for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. also used as adjunctive therapy in the management of partial seizures and for the symptomatic relief of acute alcohol withdrawal.mechanism of action benzodiazepines bind nonspecifically to benzodiazepine receptors bnz1, which mediates sleep, and bnz2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. as benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-a (gabaa) receptors, this enhances the effects of gaba by increasing gaba affinity for the gaba receptor. binding of the inhibitory neurotransmitter gaba to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.