Properties:
Spirozide is a combination of 2 diuretics agents with complementary modes of action:
Hydrochlorothiazide promotes water and sodium excretion by primary inhibition of their reabsorption at the distal tubules.
Spironolactone acts specifically by inhibiting aldosterone receptors at the distal tubules.
Both actions lead to diuresis. In addition, spironolactone minimizes potassium excretion and helps its retention in the body.

Indications:
Edema associated with congestive heart failure, nephrotic syndrome, liver cirrhosis with ascites & idiopathic edema.
Essential Hypertension.

Contraindications:
Significant renal impairment
Hyperkalemia
Acute renal failure
Acute hepatic failure
Precautions:
Patient should be evaluated for possible fluid & electrolyte disturbances, dehydration, circulatory collapse, vertigo, hypotension and lethargy.
Spirozide may raise BUN levels and cause mild acidosis in patients with impaired renal function.
Spirozide increases the half-life of digitalis, resulting in possible digitalis toxicity. Therefore, the dose of digitalis should be reduced accordingly.
Spirozide may temporarily exaggerate abnormalities of glucose metabolism.
Spirozide reduces the vascular responsiveness to noradrenaline. Therefore, caution should be exercised in managing patients subjected to anesthesia while being treated.
Thiazides were shown to alter metabolism of uric acid, precipitating high level in blood.

Warning:
Spirozide should not be taken with other potassium sparing diuretics to avoid hyperkalemia.
Thiazides have been reported to exacerbate systemic lupus erythematosus.

Dosage & route of administration & duration:
Edema: 4 tablets / day in divided doses.
Hypertension: 2 - 4 tablets / day in divided doses.
Children: 0.35 - 0.7 mg / kg body weight / day, in divided doses.
Use in pregnancy & lactation:
Spirozide may cross placental barrier and cause fetal hazards. Necessity of the drug should be weighed against this risk.
Spirozide may appear in milk of breast-feeding mothers, if necessary artificial feeding should be sought.

Side effects:
Side effects are reversible and disappear after the drug is discontinued, they include: nausea, vomiting, abdominal cramps, hypotension, fatigue, dry mouth, dizziness, pruritis and muscle pain. Rare cases of anemia, leukopenia, thrombocytopenia and dehydration have been
reported. Gynaecomastia may occur.

Storage:
Keep at temp. not exceeding 30°C
Keep medicine out of reach of children.

Presentation:
Box of 20 tablets or 1000 tablets