Pregnancy related informationcontraindicated- since amiloride and hydrochlorothiazide are contraindicated in pregnancy.breast feeding related informationcontraindicated- since amiloride and hydrochlorothiazide are contraindicated in lactation.indications for amiloride + hydrochlorothiazidehypertentiontypical dosage for amiloride + hydrochlorothiazideadults: 1 - 2 tablets / day preferably in the morning (amiloride 5mg + hydrochlorothiazide 50mg )mechanism of action of amilorideamiloride is a guanidine derivative which exerts its diuretic action by interacting with renal epithelial na+ channels in distal tubules and collecting duct and prevents sodium reabsorption. it prevents potassium lose. it also increases chloride, bicarbonate, and water excretion and decreases h+ excretion. the drug augment the natriuretic and anti hypertensive response of other drugs.