**therapeutic indications:it is indicated for the treatment of postmenopausal osteoporosis in women at risk of vitamin d insufficiency. it reduces the risk of vertebral and hip fractures.**posology and method of administrationthe recommended dose is one tablet once weekly.patients should be instructed that if they miss a dose of osteonate plus they should take one tablet on the morning after they remember. they should not take two tablets on the same day but should return to taking one tablet once a week, as originally scheduled on their chosen day.due to the nature of the disease process in osteoporosis, osteonate plus is intended for long-term use.patients should receive supplemental calcium if intake from diet is inadequate. additional supplementation with vitamin d should be considered on an individual basis taking into account any vitamin d intake from vitamins and dietary supplements.