About sulbutiaminea synthetic derivative of thiamine, a centrally acting cholinergic agent, nootropic,antiasthenic.mechanism of action of sulbutiaminesulbutiamine is a centrally acting cholinergic agent. this drug inhibits the enzyme acetyl cholinesterase and prolongs the action of acetylcholine- a stimulating hormone in the brain. this increased acetylcholine concentrations are believed to be responsible for the improvement seen during treatment with donepezil. sulbutiamine is a thiamine derivative. being lipophilic it crosses the blood brain barrier and leads to increased formation of thiamine triphosphate which regulates the synaptic transmission of many neurotransmission system.