About stavudinenucleoside reverse transcriptase inhibitor, antiretroviral agent.mechanism of action of stavudinestavudine is a thymidine nucleoside analogue. it undergoes phosphorylation in the presence of kinase enzyme and form stavudine triphosphate. this stavudine triphosphate competitively inhibit hiv reverse transcriptase enzyme which is responsible for the conversion of viral rna to pro viral dna and is then added to host cell chromosome. stavudine triphosphate terminates elongation of pro viral dna and results in inhibition of viral replication.