Indication used in the treatment of schizophrenia.mechanism of action sertindole is an antipsychotic drug with affinity for dopamine d2, serotonin 5-ht2a and 5-ht2c, and alpha1-adrenoreceptors. preclinical studies suggest that sertindole acts preferentially on limbic and cortical dopaminergic neurons and clinical trials have confirmed that sertindole is effective at a low dopamine d2 occupancy level.