Description cyclobenzaprine is a skeletal muscle relaxant and a central nervous system (cns) depressant. cyclobenzaprine acts on the locus coeruleus where it results in increased norepinephrine release, potentially through the gamma fibers which innervate and inhibit the alpha motor neurons in the ventral horn of the spinal cord. it is structurally similar to amitriptyline, differing by only one double bond.mechanism of action like other tricyclic antidepressants, cyclobenzaprine exhibits anticholinergic activity, potentiation of norepinephrine, and antagonism of reserpine. cyclobenzaprine does not directly act on the neuromuscular junction or the muscle but relieves muscle spasms through a central action, possibly at the brain stem level. cyclobenzaprine binds to the serotonin receptor and is considered a 5-ht2 receptor antagonist that reduces muscle tone by decreasing the activity of descending serotonergic neurons.