Properties and Mechanism of Action:
Prostagard is a unique drug that contains a synergistic formulation of the most potent and
standardized herbs used in the treatment and prevention of Benign Prostatic Hypertrophy (BPH).
Saw Palmetto is the first choice for the safe treatment of BPH. It inhibits the binding of
dihydrotestosterone (DHT) to the cytosolic androgenic receptor and α1-adrenoceptor in the
prostate, thus it prevents accumulation of the steroid which may lead to prostate hyperplasia.
Also it inhibits the 5 α-reductase which is responsible for the conversion of testosterone to DHT
and for the conversion of DHT to an androgen compound. Saw Palmetto is used also for
urination problems associated with BPH stage I and II.
Pygeum Africanum has an important effect in counteracting prostate hypertrophy due to a
number of mechanisms which include:
- Inhibition of prostatic cells growth factor.
- Inhibition of aromatase secretory activity of the prostatic epithelium.
- Reduction of congestion, inflammation and edema of the prostate (improves urinary function).
Pumpkin seed oil improves the tone of the bladder muscles and the decongestion of the
prostate so increases urine flow.
Bearberry has urinary antiseptic, diuretic and astringent effects.
Prostagard also contains Zinc gluconate and Vitamin B6 which act synergistically
with natural
herbs to improve urinary performance.