EPICOCILLIN (Capsules-Dry Mix)
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Description


Composition

Each dosage unit contains: Capsule 5 ml Suspension
Ampicillin (as trihydrate) 250 mg or 500 mg 125 mg or 250 mg

Excipients:
EPICOCILLIN Capsules: Maize starch, microcrystalline cellulose, talc, purified, magnesium stearate, colloidal silicon dioxide.
EPICOCILLIN Suspension: Sucrose, carboxymethylcellulose sodium, caramel aroma powder, banana aroma powder, vanillin, sodium citrate anhydrous, colloidal silicon dioxide, sodium benzoate.

Therapeutic Indications

Treatment of a variety of infections due to susceptible organisms which include:
Upper respiratory tract infections: otitis media, sinusitis, tonsillitis, septic sore throat, pharyngitis.
Lower respiratory tract infections: bronchitis, pneumonia.
Gastrointestinal and biliary tract infections: enteritis, bacillary dysentery, typhoid and paratyphoid, cholecystitis.
Genitourinary tract infections: cystitis, pyelonephritis, gonorrhoea, urethritis, adnexitis.
Other infections: septicemia, bacterial meningitis, endocarditis and soft tissue infections.

Dosage and Administration

Adults: 250 mg-1 g every 6 hours, taken at least 30 minutes before or 2 hours after food.
Children: 125-500 mg every 6 hours.
Reconstitution of EPICOCILLIN Dry Mix:
To make up, first shake the bottle to loosen powder, then add water to the content of the bottle and shake well. Fill up to line and allow to stand for 5 minutes to ensure full dispersion. After reconstitution, EPICOCILLIN Suspension should be stored in a refrigerator and used only within 10 days. Shake well before use.

Contraindications

Hypersensitivity to penicillin.
Infectious mononucleosis or lymphatic leukemia.

Warnings and Precautions

EPICOCILLIN should be used with caution in patients with a history of severe reactions to penicillins or cephalosporins.
Treatment with EPICOCILLIN should be discontinued if a skin rash occurs.
Reduced doses should be used in impaired renal function.

Drug Interactions

Allopurinol increases risk of rash when given with ampicillin.
Chloramphenicol, erythromycin, and tetracycline may reduce bactericidal effects of ampicillin.
EPICOCILLIN may interfere with the contraceptive action of estrogen oral contraceptives.
Probenecid may reduce excretion of EPICOCILLIN resulting in increased plasma concentration.
EPICOCILLIN increases bleeding effect of heparin and oral anticoagulants.