Sulphasalazinecomposed of 5-aminosalicylic acid and sulfapyridine, anti-infective (in inflammatory bowel disease),anti arthritic.mechanism of action of sulphasalazinesulfasalazine exerts its anti-inflammatory action by inhibiting lipoxygenase enzyme.
this will leads to decreased production of pro-inflammatory leukotrienes (ltb4) and 5-hydroxy eicosa tetra enoic acids (hete) in the intestinal wall.
it inhibits the production of inflammatory mediators like interleukin-1, tumor necrosis factor-alpha etcindications for sulphasalazine

1.
ulcerative colitis

2.
crohn`s disease

3.
rheumatoid arthritis

4.
diarrhea interactions for sulphasalazinefolic acid : signs of folic deficiency with sulphasalazine.
digoxin : possibly reduced efficacy of digoxin.