Cefiximethird generation cephalosporin oral antibioticmechanism of action of cefiximecefixime is an orally active 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis.
cefixime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall.
transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like cefixime.
it is highly active against enterobacteriaceae, haemophilus influenzae, streptococcus pyogens & streptococcus pneumonia &many beta lactamase producing bacteria.indications for cefixime
1.tonsillitis
2.pharyngitis
3.otitismedia
4.bronchitis
5.urinary tract infections
6.gonorrhea
7.infections caused by susceptible organisms.