About erythromycinsmacrolide antibiotic.ssmechanism of action of erythromycinserythromycin is a member of macrolide antibiotics. it binds to the 50s sub unit of bacterial ribosome and inhibits translocation.ie: they interfere with the transfer of the newly formed peptide chain from the a site to the p site and fails to expose the a site .so that a site is unable to bind with the next aminoacyl t rna complex. this leads to premature termination of amino acid chain and there by inhibits protein synthesis.ssindications for erythromycins1.tonsilitis s2.pharyngitis s3.pneumonia s4.diphtheria s5.pertusis s6.tetanus s7.sabe s8.syphilis s9.gonorrhea s10.wound and burn infection s11.rheumatic fever s12.acne s13.urogenital infection s14.chancroid s15.intestinal amoebiasis s16.skin and soft tissue infections s17.urethritis