Coronit 40mg 20 lentocaps

معلومات الدواء
الإسم التجاري Coronit 40mg 20 lentocaps -
الإسم العلمي Isosorbide dinitrate
السعر 10.00 جنيها
الشركات المنتجة Alexandria
الوصف والإستخدام
وصف الدواء بالعربية
وصف الدواء بالإنجليزية About isosorbide dinitratealkyl nitrate derivative, a direct vasodilator, antianginal.mechanism of action of isosorbide dinitrateit is a direct smooth muscle relaxant, which have a prominent action vascular smooth muscles preferentially veins than arteries. it is enzymatically denitrated in the smooth muscle cells to release the reactive free radical nitric oxide which activates cytosolic guanylyl cyclase thus increases cyclic gmp levels which causes dephosphorylation of myosin light chain kinase(mlck) through a cyclic gmp dependent protein kinase. reduced availability of phosphorylated (active) mlck interferes with activation of myosin and myosin fails to interact with actin to cause contraction and consequently relaxation occurs. elevated levels of cyclic gmp also reduce calcium entry which also contributing to relaxation. it dilates veins more than arteries because veins have greater amount of enzyme that generate nitric oxide from nitrates.

البدائل

الدواء السعر
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Nitrotard 2.5mg 60 caps. 18.00
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Pental 400mg 20 s.r.tab. 11.25
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Nitroderm tts 10mg 7 patches 51.25
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Tebofortin 40mg 30 f.c.tab. 35.00
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Tebofortin 40mg/ml oral soln. 30 ml 24.75
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Savapran 5 mg 20 f.c. tabs. 98.66
Anginitra 5mg 10 sublingual tab. 0.75
Trentoximal 20mg/ml 5 amp. 26.00
Tricardia mr 35mg 30 f.c. tabs. 19.00
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Cardiocare 2.5mg 60 s.r.caps. 15.00
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Angilow 10mg 30 tab. 7.00
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Angiobradine 7.5 mg 10 f.c. tabs. 58.50