About ropivacaineamide type local anaestheticsmechanism of action of ropivacaineropivacaine blocks both initiation and conduction of nerve impulses by decreasing the neuronal membrane s permeability to sodium ions, resulting in inhibition of depolarisation with resultant blockade of conductionindications for ropivacaine1.surgical anaesthesia 2.acute pain interactions for ropivacaineitraconazole, ketoconazole or clarithromycin may reduce clearance of ropivacaine increased metabolism when used with rifampicin clearance is inhibited when used with fluvoxamine or ciprofloxacin increased risk of toxicity when used with other local anaesthetics