About simethiconeoral anti-foaming agent, silicones, antiflatulent.mechanism of action of simethiconethis anti-gas (anti-flatulence) medication acts in the stomach and intestines to change the surface tension of gas bubbles, enabling smaller bubbles to join together into bigger bubbles. it results elimination of gas more easily by belching or passing flatus.indications for simethicone1. abdominal pain which is due to excessive gas in the digestive tract 2. before gastroscopy or radiography of the bowel typical dosage for simethiconeoral- adults and teenagers- 60 -125mg four times a day, after meals and at bedtime. not more than 500 mg should be taken in twenty-four hours. chewable tablets: adults and teenagers- 40 -125 mg four times a day, after meals and at bedtime or 150 mg three times a day, after meals. not more than 500 mg should be taken in twenty-four hours. suspension: adults and teenagers- 40 -95 mg four times a day, after meals and at bedtime.