Indication for the treatment of hypocalcemia in those conditions requiring a prompt increase in blood plasma calcium levels, for the treatment of magnesium intoxication due to overdosage of magnesium sulfate, and used to combat the deleterious effects of hyperkalemia as measured by electrocardiographic (ecg), pending correction of the increased potassium level in the extracellular fluid.mechanism of action calcium chloride in water dissociates to provide calcium (ca2+) and chloride (cl-) ions. they are normal constituents of the body fluids and are dependent on various physiological mechanisms for maintenance of balance between intake and output. for hyperkalemia, the influx of calcium helps restore the normal gradient between threshold potential and resting membrane potential.